Drug interactions
Fluvoxamine + Lorcaserin
Severity: Major
Fluvoxamine and Lorcaserin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorcaserin is a serotonin 5-HT2C agonist, and combining it with an SSRI may increase the risk of serotonin syndrome or related reactions. Lorcaserin has been withdrawn from the US market, so this is mostly relevant for historical or legacy use.
What this interaction means in plain words
Fluvoxamine and Lorcaserin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive serotonergic activity from 5-HT2C agonism and serotonin reuptake inhibition.
What to do
Avoid the combination; if unavoidable, monitor closely for signs of serotonin syndrome and stop lorcaserin if they appear.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Lorcaserin?
MediHelp rates the interaction as major. Fluvoxamine and Lorcaserin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lorcaserin is a serotonin 5-HT2C agonist, and combining it with an SSRI may increase the risk of serotonin syndrome or related reactions. Lorcaserin has been withdrawn from the US market, so this is mostly relevant for historical or legacy use.
How serious is the interaction between Fluvoxamine and Lorcaserin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if unavoidable, monitor closely for signs of serotonin syndrome and stop lorcaserin if they appear.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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