Drug interactions
Fluvoxamine + Lsd
Severity: Moderate
Fluvoxamine and Lsd: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
LSD is a serotonin receptor agonist, and SSRIs generally blunt its subjective effects through receptor downregulation. Combined use has been associated with unpredictable responses, and serotonin toxicity is a theoretical risk.
What this interaction means in plain words
Fluvoxamine and Lsd can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
LSD agonism at serotonin 5-HT2A receptors overlaps with enhanced serotonergic tone from fluvoxamine; the clinical interaction is incompletely characterized.
What to do
Advise patients to avoid LSD while on fluvoxamine and monitor for agitation, hyperthermia or tremor if exposure occurs. Seek emergency care if serotonin syndrome symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluvoxamine and Lsd, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Lsd?
MediHelp rates the interaction as moderate. Fluvoxamine and Lsd can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. LSD is a serotonin receptor agonist, and SSRIs generally blunt its subjective effects through receptor downregulation. Combined use has been associated with unpredictable responses, and serotonin toxicity is a theoretical risk.
How serious is the interaction between Fluvoxamine and Lsd?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid LSD while on fluvoxamine and monitor for agitation, hyperthermia or tremor if exposure occurs. Seek emergency care if serotonin syndrome symptoms appear.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
