Drug interactions
Fluvoxamine + Meclofenamate
Severity: Major
Fluvoxamine and Meclofenamate: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs impair platelet aggregation and NSAIDs such as meclofenamate inhibit platelets and irritate the gastric mucosa. The combination raises the risk of gastrointestinal bleeding.
What this interaction means in plain words
Fluvoxamine and Meclofenamate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive platelet dysfunction from SSRI serotonin depletion and NSAID cyclooxygenase inhibition, with NSAID mucosal injury.
What to do
Avoid the combination if possible, or use the lowest NSAID dose for the shortest time with a proton pump inhibitor in at-risk patients. Watch for black stools or other signs of bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Meclofenamate?
MediHelp rates the interaction as major. Fluvoxamine and Meclofenamate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. SSRIs impair platelet aggregation and NSAIDs such as meclofenamate inhibit platelets and irritate the gastric mucosa. The combination raises the risk of gastrointestinal bleeding.
How serious is the interaction between Fluvoxamine and Meclofenamate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, or use the lowest NSAID dose for the shortest time with a proton pump inhibitor in at-risk patients. Watch for black stools or other signs of bleeding.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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