Drug interactions
fluvoxamine + metformin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
SSRIs (including fluvoxamine) may alter glycemic control, with reports of hypo- or hyperglycemia in patients on antidiabetic therapy.
Mechanism of action
Unknown; likely pharmacodynamic effects of SSRIs on glucose homeostasis rather than a PK interaction (metformin is renally eliminated).
Clinical management
Monitor fasting glucose and A1c when starting, stopping, or changing fluvoxamine dose; adjust antidiabetic regimen as needed and counsel on symptoms of hypo-/hyperglycemia.
Drug reference
Frequently asked questions
Can I take fluvoxamine with metformin?
The interaction is rated: Moderate. SSRIs (including fluvoxamine) may alter glycemic control, with reports of hypo- or hyperglycemia in patients on antidiabetic therapy.
How serious is the interaction between fluvoxamine and metformin?
The interaction is rated: Moderate. Evidence level: Moderate.
How is the interaction between fluvoxamine and metformin managed?
Monitor fasting glucose and A1c when starting, stopping, or changing fluvoxamine dose; adjust antidiabetic regimen as needed and counsel on symptoms of hypo-/hyperglycemia.
Why do fluvoxamine and metformin interact?
Unknown; likely pharmacodynamic effects of SSRIs on glucose homeostasis rather than a PK interaction (metformin is renally eliminated).
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