Drug interactions
Fluvoxamine + Metoclopramide intranasal
Severity: Moderate
Fluvoxamine and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide is a dopamine antagonist that can cause extrapyramidal symptoms and neuroleptic malignant syndrome, and serotonergic antidepressants may increase these risks. Serotonin syndrome has also been reported with the combination.
What this interaction means in plain words
Fluvoxamine and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive dopaminergic blockade and serotonergic effects may increase extrapyramidal and serotonin toxicity.
What to do
Monitor for tremor, rigidity, akathisia, agitation and hyperthermia; consider an alternative antiemetic if movement symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Fluvoxamine and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide is a dopamine antagonist that can cause extrapyramidal symptoms and neuroleptic malignant syndrome, and serotonergic antidepressants may increase these risks. Serotonin syndrome has also been reported with the combination.
How serious is the interaction between Fluvoxamine and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tremor, rigidity, akathisia, agitation and hyperthermia; consider an alternative antiemetic if movement symptoms appear.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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