Drug interactions
Fluvoxamine + Mobocertinib
Severity: Major
Fluvoxamine and Mobocertinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mobocertinib is a CYP3A4 substrate that prolongs the QTc interval, and moderate CYP3A4 inhibitors raise its exposure and the risk of torsades de pointes. Fluvoxamine can also itself prolong QT modestly.
What this interaction means in plain words
Fluvoxamine and Mobocertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
CYP3A4 inhibition by fluvoxamine increases mobocertinib exposure, with additive QT effects.
What to do
Avoid if possible and choose an antidepressant without CYP3A4 inhibition; if unavoidable, reduce the mobocertinib dose as labeled and monitor ECG and electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Mobocertinib?
MediHelp rates the interaction as major. Fluvoxamine and Mobocertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mobocertinib is a CYP3A4 substrate that prolongs the QTc interval, and moderate CYP3A4 inhibitors raise its exposure and the risk of torsades de pointes. Fluvoxamine can also itself prolong QT modestly.
How serious is the interaction between Fluvoxamine and Mobocertinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and choose an antidepressant without CYP3A4 inhibition; if unavoidable, reduce the mobocertinib dose as labeled and monitor ECG and electrolytes.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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