Drug interactions
Fluvoxamine + Nirogacestat
Severity: Moderate
Fluvoxamine and Nirogacestat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nirogacestat is a CYP3A4 substrate, and inhibitors raise its exposure, which may increase diarrhea, hepatotoxicity and other adverse effects. Fluvoxamine is a weak to moderate CYP3A4 inhibitor.
What this interaction means in plain words
Fluvoxamine and Nirogacestat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Nirogacestat belongs to Oncology.
Why it happens
Fluvoxamine inhibits CYP3A4, decreasing nirogacestat metabolism.
What to do
Consider an antidepressant with less CYP3A4 inhibition; if coadministered, monitor liver tests and gastrointestinal toxicity and adjust nirogacestat per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Nirogacestat
Frequently asked questions
Can I take Fluvoxamine with Nirogacestat?
MediHelp rates the interaction as moderate. Fluvoxamine and Nirogacestat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nirogacestat is a CYP3A4 substrate, and inhibitors raise its exposure, which may increase diarrhea, hepatotoxicity and other adverse effects. Fluvoxamine is a weak to moderate CYP3A4 inhibitor.
How serious is the interaction between Fluvoxamine and Nirogacestat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an antidepressant with less CYP3A4 inhibition; if coadministered, monitor liver tests and gastrointestinal toxicity and adjust nirogacestat per labeling.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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