Drug interactions
Fluvoxamine + Octreotide
Severity: Moderate
Fluvoxamine and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide can cause bradycardia and QT prolongation, and fluvoxamine has a small QT effect, so the combination may modestly add to arrhythmia risk. The risk is greater with bradycardia, electrolyte disturbances or heart disease.
What this interaction means in plain words
Fluvoxamine and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Octreotide belongs to Endocrine.
Why it happens
Additive QT prolongation and bradycardic effects.
What to do
Check baseline ECG and electrolytes in patients with cardiac risk factors and monitor the QTc and heart rate. Correct hypokalemia and hypomagnesemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Octreotide
Frequently asked questions
Can I take Fluvoxamine with Octreotide?
MediHelp rates the interaction as moderate. Fluvoxamine and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide can cause bradycardia and QT prolongation, and fluvoxamine has a small QT effect, so the combination may modestly add to arrhythmia risk. The risk is greater with bradycardia, electrolyte disturbances or heart disease.
How serious is the interaction between Fluvoxamine and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes in patients with cardiac risk factors and monitor the QTc and heart rate. Correct hypokalemia and hypomagnesemia.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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