Drug interactions
Fluvoxamine + Pimozide
Severity: Contraindicated
Fluvoxamine and Pimozide: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine can raise pimozide concentrations through CYP inhibition, and pimozide is a potent QT-prolonging drug with a narrow therapeutic margin. The combination may precipitate torsades de pointes and sudden cardiac death.
What this interaction means in plain words
Fluvoxamine and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fluvoxamine belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Why it happens
Inhibition of pimozide metabolism (CYP3A4 and CYP1A2) by fluvoxamine, with additive QT prolongation.
What to do
Do not co-administer; select an alternative antidepressant or antipsychotic. If already combined, stop one drug and obtain an ECG.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Pimozide?
MediHelp rates the interaction as contraindicated. Fluvoxamine and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fluvoxamine can raise pimozide concentrations through CYP inhibition, and pimozide is a potent QT-prolonging drug with a narrow therapeutic margin. The combination may precipitate torsades de pointes and sudden cardiac death.
How serious is the interaction between Fluvoxamine and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; select an alternative antidepressant or antipsychotic. If already combined, stop one drug and obtain an ECG.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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