Drug interactions
Fluvoxamine + Rabeprazole
Severity: Minor
Fluvoxamine and Rabeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine strongly inhibits CYP2C19 and may raise rabeprazole levels. Rabeprazole is mostly cleared non-enzymatically, so the clinical impact is usually small.
What this interaction means in plain words
Fluvoxamine and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluvoxamine belongs to Central Nervous System; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
Fluvoxamine inhibits CYP2C19, reducing the enzymatic metabolism of rabeprazole.
What to do
No routine dose adjustment is needed; monitor for PPI adverse effects such as headache or gastrointestinal upset.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Rabeprazole?
MediHelp rates the interaction as minor. Fluvoxamine and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluvoxamine strongly inhibits CYP2C19 and may raise rabeprazole levels. Rabeprazole is mostly cleared non-enzymatically, so the clinical impact is usually small.
How serious is the interaction between Fluvoxamine and Rabeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment is needed; monitor for PPI adverse effects such as headache or gastrointestinal upset.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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