Drug interactions
Fluvoxamine + Remimazolam
Severity: Moderate
Fluvoxamine and Remimazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Remimazolam is a benzodiazepine sedative, and other CNS depressants can intensify its effects. Fluvoxamine can contribute sedation, so deeper sedation and respiratory depression may occur during procedures.
What this interaction means in plain words
Fluvoxamine and Remimazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Remimazolam belongs to Central Nervous System.
Why it happens
Additive CNS depression through pharmacodynamic effects.
What to do
Titrate remimazolam carefully, with continuous monitoring of oxygen saturation and vital signs during and after the procedure. Have resuscitation equipment available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Remimazolam
Frequently asked questions
Can I take Fluvoxamine with Remimazolam?
MediHelp rates the interaction as moderate. Fluvoxamine and Remimazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Remimazolam is a benzodiazepine sedative, and other CNS depressants can intensify its effects. Fluvoxamine can contribute sedation, so deeper sedation and respiratory depression may occur during procedures.
How serious is the interaction between Fluvoxamine and Remimazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate remimazolam carefully, with continuous monitoring of oxygen saturation and vital signs during and after the procedure. Have resuscitation equipment available.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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