Drug interactions
Fluvoxamine + Romidepsin
Severity: Major
Fluvoxamine and Romidepsin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT interval prolongation, and the combination may increase the risk of ventricular arrhythmias including torsades de pointes. Risk is higher with electrolyte disturbances or underlying heart disease. Fluvoxamine may also raise romidepsin levels through CYP3A4 inhibition.
What this interaction means in plain words
Fluvoxamine and Romidepsin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation, with possible CYP3A4 inhibition raising romidepsin exposure.
What to do
Obtain a baseline ECG and monitor ECG and potassium and magnesium during therapy; correct electrolytes and consider an alternative antidepressant with lower QT liability if the interval lengthens.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Romidepsin?
MediHelp rates the interaction as major. Fluvoxamine and Romidepsin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs have been associated with QT interval prolongation, and the combination may increase the risk of ventricular arrhythmias including torsades de pointes. Risk is higher with electrolyte disturbances or underlying heart disease. Fluvoxamine may also raise romidepsin levels through CYP3A4 inhibition.
How serious is the interaction between Fluvoxamine and Romidepsin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor ECG and potassium and magnesium during therapy; correct electrolytes and consider an alternative antidepressant with lower QT liability if the interval lengthens.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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