Drug interactions
Fluvoxamine + Salicylates
Severity: Moderate
Fluvoxamine and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an SSRI with a salicylate increases the risk of bleeding, especially from the upper gastrointestinal tract. Both impair platelet function and salicylates can irritate gastric mucosa.
What this interaction means in plain words
Fluvoxamine and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive impairment of platelet function (SSRI platelet serotonin depletion plus salicylate effects) and mucosal injury.
What to do
Monitor for signs of GI bleeding and consider a proton pump inhibitor in patients at higher risk; avoid unnecessary long-term salicylate use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Salicylates?
MediHelp rates the interaction as moderate. Fluvoxamine and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an SSRI with a salicylate increases the risk of bleeding, especially from the upper gastrointestinal tract. Both impair platelet function and salicylates can irritate gastric mucosa.
How serious is the interaction between Fluvoxamine and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of GI bleeding and consider a proton pump inhibitor in patients at higher risk; avoid unnecessary long-term salicylate use.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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