Drug interactions
Fluvoxamine + Salsalate
Severity: Moderate
Fluvoxamine and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs combined with NSAID-type agents such as salsalate increase the risk of gastrointestinal bleeding. Salsalate has a weaker antiplatelet effect than aspirin, but the risk is still raised.
What this interaction means in plain words
Fluvoxamine and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on hemostasis through SSRI-induced platelet serotonin depletion and salicylate mucosal and platelet effects.
What to do
Monitor for bleeding symptoms and consider gastroprotection with a proton pump inhibitor in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Salsalate?
MediHelp rates the interaction as moderate. Fluvoxamine and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SSRIs combined with NSAID-type agents such as salsalate increase the risk of gastrointestinal bleeding. Salsalate has a weaker antiplatelet effect than aspirin, but the risk is still raised.
How serious is the interaction between Fluvoxamine and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding symptoms and consider gastroprotection with a proton pump inhibitor in high-risk patients.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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