Drug interactions
Fluvoxamine + Same
Severity: Moderate
Fluvoxamine and Same: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
S-adenosylmethionine (SAMe) may increase serotonergic activity, and combining it with an SSRI could raise the risk of serotonin syndrome. Evidence consists mainly of case reports and theoretical concern.
What this interaction means in plain words
Fluvoxamine and Same can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic effects; SAMe may increase monoamine neurotransmitter turnover.
What to do
Avoid unsupervised combination and monitor for agitation, tremor, diarrhea and hyperthermia if used together. Discontinue SAMe if serotonin toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Same?
MediHelp rates the interaction as moderate. Fluvoxamine and Same can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. S-adenosylmethionine (SAMe) may increase serotonergic activity, and combining it with an SSRI could raise the risk of serotonin syndrome. Evidence consists mainly of case reports and theoretical concern.
How serious is the interaction between Fluvoxamine and Same?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unsupervised combination and monitor for agitation, tremor, diarrhea and hyperthermia if used together. Discontinue SAMe if serotonin toxicity is suspected.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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