Drug interactions
Fluvoxamine + Selegiline transdermal
Severity: Contraindicated
Fluvoxamine and Selegiline transdermal: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Transdermal selegiline at antidepressant doses inhibits MAO-A and MAO-B, and combining it with an SSRI can cause serotonin syndrome and hypertensive reactions. Labeling contraindicates SSRIs with this product.
What this interaction means in plain words
Fluvoxamine and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Nonselective MAO inhibition by selegiline combined with serotonin reuptake inhibition causes excess serotonin.
What to do
Do not combine; stop fluvoxamine at least 1 to 2 weeks before starting transdermal selegiline and allow at least 2 weeks after stopping selegiline before starting fluvoxamine.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Selegiline transdermal?
MediHelp rates the interaction as contraindicated. Fluvoxamine and Selegiline transdermal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Transdermal selegiline at antidepressant doses inhibits MAO-A and MAO-B, and combining it with an SSRI can cause serotonin syndrome and hypertensive reactions. Labeling contraindicates SSRIs with this product.
How serious is the interaction between Fluvoxamine and Selegiline transdermal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; stop fluvoxamine at least 1 to 2 weeks before starting transdermal selegiline and allow at least 2 weeks after stopping selegiline before starting fluvoxamine.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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