Drug interactions
Fluvoxamine + Triazolam
Severity: Moderate
Fluvoxamine and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine can raise triazolam concentrations, mainly through CYP3A4 inhibition, with a weaker effect than strong inhibitors. Increased exposure may cause deeper sedation, psychomotor impairment and amnesia.
What this interaction means in plain words
Fluvoxamine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fluvoxamine inhibits CYP3A4-mediated metabolism of triazolam, reducing its clearance.
What to do
Start with a lower triazolam dose and titrate according to response. Warn patients about next-day drowsiness and impaired driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Triazolam?
MediHelp rates the interaction as moderate. Fluvoxamine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvoxamine can raise triazolam concentrations, mainly through CYP3A4 inhibition, with a weaker effect than strong inhibitors. Increased exposure may cause deeper sedation, psychomotor impairment and amnesia.
How serious is the interaction between Fluvoxamine and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a lower triazolam dose and titrate according to response. Warn patients about next-day drowsiness and impaired driving.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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