Drug interactions
Fluvoxamine + Trifluoperazine
Severity: Moderate
Fluvoxamine and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and fluvoxamine may raise phenothiazine levels via CYP inhibition. The combination increases the risk of arrhythmia and additive sedation.
What this interaction means in plain words
Fluvoxamine and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation with possible CYP-mediated increase in trifluoperazine exposure.
What to do
Obtain a baseline ECG and monitor QTc, correcting electrolyte abnormalities. Use the lowest effective antipsychotic dose and watch for extrapyramidal and sedative effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Fluvoxamine with Trifluoperazine?
MediHelp rates the interaction as moderate. Fluvoxamine and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and fluvoxamine may raise phenothiazine levels via CYP inhibition. The combination increases the risk of arrhythmia and additive sedation.
How serious is the interaction between Fluvoxamine and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc, correcting electrolyte abnormalities. Use the lowest effective antipsychotic dose and watch for extrapyramidal and sedative effects.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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