Drug interactions
Fluvoxamine + Zanubrutinib
Severity: Moderate
Fluvoxamine and Zanubrutinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zanubrutinib is metabolized mainly by CYP3A4, and fluvoxamine can increase its exposure. This raises the risk of adverse effects such as bleeding, cytopenias and infections.
What this interaction means in plain words
Fluvoxamine and Zanubrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvoxamine belongs to Central Nervous System; Zanubrutinib belongs to Oncology.
Why it happens
CYP3A4 inhibition by fluvoxamine reduces zanubrutinib clearance.
What to do
Reduce zanubrutinib to 80 mg twice daily during co-administration per labeling. Monitor blood counts and for bleeding or infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Zanubrutinib
Frequently asked questions
Can I take Fluvoxamine with Zanubrutinib?
MediHelp rates the interaction as moderate. Fluvoxamine and Zanubrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zanubrutinib is metabolized mainly by CYP3A4, and fluvoxamine can increase its exposure. This raises the risk of adverse effects such as bleeding, cytopenias and infections.
How serious is the interaction between Fluvoxamine and Zanubrutinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce zanubrutinib to 80 mg twice daily during co-administration per labeling. Monitor blood counts and for bleeding or infection.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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