Drug interactions
Folic acid + Glipizide-metformin
Severity: Minor
Folic acid and Glipizide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metformin has been associated with lower folate levels in some patients, although the clinical relevance is uncertain and much less established than for vitamin B12. Folic acid supplementation is not harmful with metformin.
What this interaction means in plain words
Folic acid and Glipizide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Folic acid belongs to Miscellaneous; Glipizide-metformin belongs to Endocrine.
Why it happens
The mechanism is not established, but altered intestinal absorption has been suggested.
What to do
No routine action is needed; consider checking folate in patients with unexplained anemia or poor nutrition.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide-metformin
Other interactions of Folic acid
- Ethotoin + Folic acid Moderate
- Folic acid + Fosphenytoin Moderate
- Folic acid + Glucarpidase Moderate
- Folic acid + Methotrexate Moderate
- Folic acid + Pafolacianine Moderate
- Folic acid + Phenobarbital Moderate
Frequently asked questions
Can I take Folic acid with Glipizide-metformin?
MediHelp rates the interaction as minor. Folic acid and Glipizide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metformin has been associated with lower folate levels in some patients, although the clinical relevance is uncertain and much less established than for vitamin B12. Folic acid supplementation is not harmful with metformin.
How serious is the interaction between Folic acid and Glipizide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; consider checking folate in patients with unexplained anemia or poor nutrition.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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