Drug interactions
Glucarpidase + Pralatrexate
Severity: Minor
Glucarpidase and Pralatrexate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucarpidase cleaves glutamate from folates and classical antifolates, so pralatrexate, a folate analogue, may be inactivated if exposed to the enzyme. This could reduce pralatrexate efficacy, though the combination is rarely needed in practice.
What this interaction means in plain words
Glucarpidase and Pralatrexate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glucarpidase belongs to Miscellaneous; Pralatrexate belongs to Oncology.
Why it happens
Glucarpidase hydrolyzes the glutamate residue of antifolates, potentially degrading pralatrexate.
What to do
Do not time pralatrexate doses near glucarpidase administration unless necessary, and assess antitumor response if glucarpidase was given.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pralatrexate
Other interactions of Glucarpidase
- Glucarpidase + Leucovorin Major
- Folic acid + Glucarpidase Moderate
- Glucarpidase + Methotrexate Moderate
- Glucarpidase + Pemetrexed Minor
Frequently asked questions
Can I take Glucarpidase with Pralatrexate?
MediHelp rates the interaction as minor. Glucarpidase and Pralatrexate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glucarpidase cleaves glutamate from folates and classical antifolates, so pralatrexate, a folate analogue, may be inactivated if exposed to the enzyme. This could reduce pralatrexate efficacy, though the combination is rarely needed in practice.
How serious is the interaction between Glucarpidase and Pralatrexate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not time pralatrexate doses near glucarpidase administration unless necessary, and assess antitumor response if glucarpidase was given.
What other medicines interact with Pralatrexate?
MediHelp also lists interactions of Pralatrexate with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Brexucabtagene autoleucel. The full list is on the Pralatrexate page.
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