Drug interactions
Glucarpidase + Pemetrexed
Severity: Minor
Glucarpidase and Pemetrexed: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucarpidase is an enzyme that cleaves the glutamate residue from folates and classical antifolates. Pemetrexed has a glutamate moiety and may therefore be hydrolyzed, which could lower its exposure and reduce antitumor effect if given close in time. The clinical relevance is uncertain because glucarpidase is used for methotrexate toxicity.
What this interaction means in plain words
Glucarpidase and Pemetrexed have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glucarpidase belongs to Miscellaneous; Pemetrexed belongs to Oncology.
Why it happens
Glucarpidase hydrolyzes the terminal glutamate of antifolates, potentially inactivating pemetrexed.
What to do
Avoid giving pemetrexed within the period around a glucarpidase dose unless clinically required, and review the intended pemetrexed schedule if glucarpidase is used for methotrexate rescue.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pemetrexed
Other interactions of Glucarpidase
- Glucarpidase + Leucovorin Major
- Folic acid + Glucarpidase Moderate
- Glucarpidase + Methotrexate Moderate
- Glucarpidase + Pralatrexate Minor
Frequently asked questions
Can I take Glucarpidase with Pemetrexed?
MediHelp rates the interaction as minor. Glucarpidase and Pemetrexed have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glucarpidase is an enzyme that cleaves the glutamate residue from folates and classical antifolates. Pemetrexed has a glutamate moiety and may therefore be hydrolyzed, which could lower its exposure and reduce antitumor effect if given close in time. The clinical relevance is uncertain because glucarpidase is used for methotrexate toxicity.
How serious is the interaction between Glucarpidase and Pemetrexed?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving pemetrexed within the period around a glucarpidase dose unless clinically required, and review the intended pemetrexed schedule if glucarpidase is used for methotrexate rescue.
What other medicines interact with Pemetrexed?
MediHelp also lists interactions of Pemetrexed with, for example, Bacitracin, Brexucabtagene autoleucel, Celecoxib. The full list is on the Pemetrexed page.
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