Drug interactions
Folic acid + Metformin-repaglinide
Severity: Minor
Folic acid and Metformin-repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metformin has been associated with lower folate levels in some patients, though this is much less established than its effect on vitamin B12. The clinical significance is small.
What this interaction means in plain words
Folic acid and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Folic acid belongs to Miscellaneous; Metformin-repaglinide belongs to Endocrine.
Why it happens
Mechanism is not established; possible reduced intestinal absorption.
What to do
No routine action is needed. Consider checking folate if macrocytosis or unexplained anemia develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Folic acid
- Ethotoin + Folic acid Moderate
- Folic acid + Fosphenytoin Moderate
- Folic acid + Glucarpidase Moderate
- Folic acid + Methotrexate Moderate
- Folic acid + Pafolacianine Moderate
- Folic acid + Phenobarbital Moderate
Frequently asked questions
Can I take Folic acid with Metformin-repaglinide?
MediHelp rates the interaction as minor. Folic acid and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metformin has been associated with lower folate levels in some patients, though this is much less established than its effect on vitamin B12. The clinical significance is small.
How serious is the interaction between Folic acid and Metformin-repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Consider checking folate if macrocytosis or unexplained anemia develops.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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