Drug interactions
Folic acid + Triamterene
Severity: Minor
Folic acid and Triamterene: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triamterene is a weak folate antagonist because it inhibits dihydrofolate reductase. Long-term use may lower folate status, particularly in patients with poor intake, alcohol use or other antifolate exposure.
What this interaction means in plain words
Folic acid and Triamterene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Folic acid belongs to Miscellaneous; Triamterene belongs to Cardiovascular.
Why it happens
Weak inhibition of dihydrofolate reductase by triamterene reduces folate activation.
What to do
Monitor folate levels and blood counts in long-term users at risk of deficiency, and supplement if deficiency is found.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Other interactions of Folic acid
- Ethotoin + Folic acid Moderate
- Folic acid + Fosphenytoin Moderate
- Folic acid + Glucarpidase Moderate
- Folic acid + Methotrexate Moderate
- Folic acid + Pafolacianine Moderate
- Folic acid + Phenobarbital Moderate
Frequently asked questions
Can I take Folic acid with Triamterene?
MediHelp rates the interaction as minor. Folic acid and Triamterene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Triamterene is a weak folate antagonist because it inhibits dihydrofolate reductase. Long-term use may lower folate status, particularly in patients with poor intake, alcohol use or other antifolate exposure.
How serious is the interaction between Folic acid and Triamterene?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor folate levels and blood counts in long-term users at risk of deficiency, and supplement if deficiency is found.
What other medicines interact with Triamterene?
MediHelp also lists interactions of Triamterene with, for example, Amiloride, Eplerenone, Potassium citrate / citric acid. The full list is on the Triamterene page.
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