Drug interactions
Fondaparinux + Ginkgo biloba
Severity: Moderate
Fondaparinux and Ginkgo biloba: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ginkgo contains ginkgolides that antagonize platelet-activating factor, and bleeding has been reported in case reports with anticoagulants. Combined with fondaparinux, bleeding risk may be increased.
What this interaction means in plain words
Fondaparinux and Ginkgo biloba can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ginkgolide-mediated inhibition of platelet-activating factor adds to factor Xa inhibition.
What to do
Advise patients to avoid ginkgo during fondaparinux therapy, and monitor for bleeding if it continues.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fondaparinux
- Defibrotide + Fondaparinux Contraindicated
- Fondaparinux + Ketorolac Contraindicated
- Abciximab + Fondaparinux Major
- Aceclofenac + Fondaparinux Major
- Acetylsalicylic acid + Fondaparinux Major
- Alteplase + Fondaparinux Major
Frequently asked questions
Can I take Fondaparinux with Ginkgo biloba?
MediHelp rates the interaction as moderate. Fondaparinux and Ginkgo biloba can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ginkgo contains ginkgolides that antagonize platelet-activating factor, and bleeding has been reported in case reports with anticoagulants. Combined with fondaparinux, bleeding risk may be increased.
How serious is the interaction between Fondaparinux and Ginkgo biloba?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid ginkgo during fondaparinux therapy, and monitor for bleeding if it continues.
What other medicines interact with Fondaparinux?
MediHelp also lists interactions of Fondaparinux with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Fondaparinux page.
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