Drug interactions
Fondaparinux + Hydrocortisone
Severity: Moderate
Fondaparinux and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids have variable effects on coagulation and may also raise bleeding risk through gastrointestinal mucosal injury and vascular fragility. Combined with fondaparinux, this may increase bleeding risk, although the interaction is not well characterized.
What this interaction means in plain words
Fondaparinux and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fondaparinux belongs to Cardiovascular; Hydrocortisone belongs to Endocrine.
Why it happens
Pharmacodynamic: corticosteroid-related mucosal and vascular effects add to factor Xa-mediated anticoagulation; the mechanism is not firmly established.
What to do
Monitor for signs of bleeding and hemoglobin during co-therapy; INR is not useful for fondaparinux, so rely on clinical assessment and anti-Xa levels if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Fondaparinux
- Defibrotide + Fondaparinux Contraindicated
- Fondaparinux + Ketorolac Contraindicated
- Abciximab + Fondaparinux Major
- Aceclofenac + Fondaparinux Major
- Acetylsalicylic acid + Fondaparinux Major
- Alteplase + Fondaparinux Major
Frequently asked questions
Can I take Fondaparinux with Hydrocortisone?
MediHelp rates the interaction as moderate. Fondaparinux and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids have variable effects on coagulation and may also raise bleeding risk through gastrointestinal mucosal injury and vascular fragility. Combined with fondaparinux, this may increase bleeding risk, although the interaction is not well characterized.
How serious is the interaction between Fondaparinux and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and hemoglobin during co-therapy; INR is not useful for fondaparinux, so rely on clinical assessment and anti-Xa levels if needed.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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