Drug interactions
Fondaparinux + Meclofenamate
Severity: Moderate
Fondaparinux and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamate is an NSAID that impairs platelet aggregation and can injure the gastric mucosa. Taken with fondaparinux it increases the likelihood of clinically significant bleeding.
What this interaction means in plain words
Fondaparinux and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects: NSAID platelet inhibition and GI mucosal damage plus anti-Xa anticoagulation.
What to do
Prefer a non-NSAID analgesic. If an NSAID is needed, use the lowest dose for the shortest time and monitor for bleeding signs and hemoglobin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fondaparinux
- Defibrotide + Fondaparinux Contraindicated
- Fondaparinux + Ketorolac Contraindicated
- Abciximab + Fondaparinux Major
- Aceclofenac + Fondaparinux Major
- Acetylsalicylic acid + Fondaparinux Major
- Alteplase + Fondaparinux Major
Frequently asked questions
Can I take Fondaparinux with Meclofenamate?
MediHelp rates the interaction as moderate. Fondaparinux and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclofenamate is an NSAID that impairs platelet aggregation and can injure the gastric mucosa. Taken with fondaparinux it increases the likelihood of clinically significant bleeding.
How serious is the interaction between Fondaparinux and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-NSAID analgesic. If an NSAID is needed, use the lowest dose for the shortest time and monitor for bleeding signs and hemoglobin.
What other medicines interact with Fondaparinux?
MediHelp also lists interactions of Fondaparinux with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Fondaparinux page.
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