Drug interactions
Fondaparinux + Nettle
Severity: Minor
Fondaparinux and Nettle: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nettle has been proposed to affect coagulation, possibly through vitamin K content, but the direction and size of any effect are unclear. Fondaparinux acts independently of vitamin K, so a meaningful interaction is unlikely.
What this interaction means in plain words
Fondaparinux and Nettle have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No established mechanism; theoretical effects on coagulation from herbal constituents.
What to do
No dose change is needed. Monitor for bleeding or thrombosis if the patient takes nettle products regularly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fondaparinux
- Defibrotide + Fondaparinux Contraindicated
- Fondaparinux + Ketorolac Contraindicated
- Abciximab + Fondaparinux Major
- Aceclofenac + Fondaparinux Major
- Acetylsalicylic acid + Fondaparinux Major
- Alteplase + Fondaparinux Major
Frequently asked questions
Can I take Fondaparinux with Nettle?
MediHelp rates the interaction as minor. Fondaparinux and Nettle have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nettle has been proposed to affect coagulation, possibly through vitamin K content, but the direction and size of any effect are unclear. Fondaparinux acts independently of vitamin K, so a meaningful interaction is unlikely.
How serious is the interaction between Fondaparinux and Nettle?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor for bleeding or thrombosis if the patient takes nettle products regularly.
What other medicines interact with Fondaparinux?
MediHelp also lists interactions of Fondaparinux with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Fondaparinux page.
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