Drug interactions
Fondaparinux + Parecoxib
Severity: Moderate
Fondaparinux and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib, converted to the COX-2 inhibitor valdecoxib, has less antiplatelet effect than nonselective NSAIDs but can still cause GI bleeding. Combined with fondaparinux, bleeding risk is somewhat increased.
What this interaction means in plain words
Fondaparinux and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive: COX-2 inhibitor mucosal and renal effects with factor Xa inhibition; renal impairment may raise fondaparinux exposure.
What to do
Use the lowest effective parecoxib dose for a short period and monitor for bleeding and renal function. Consider paracetamol as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fondaparinux and Parecoxib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fondaparinux
- Defibrotide + Fondaparinux Contraindicated
- Fondaparinux + Ketorolac Contraindicated
- Abciximab + Fondaparinux Major
- Aceclofenac + Fondaparinux Major
- Acetylsalicylic acid + Fondaparinux Major
- Alteplase + Fondaparinux Major
Frequently asked questions
Can I take Fondaparinux with Parecoxib?
MediHelp rates the interaction as moderate. Fondaparinux and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parecoxib, converted to the COX-2 inhibitor valdecoxib, has less antiplatelet effect than nonselective NSAIDs but can still cause GI bleeding. Combined with fondaparinux, bleeding risk is somewhat increased.
How serious is the interaction between Fondaparinux and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective parecoxib dose for a short period and monitor for bleeding and renal function. Consider paracetamol as an alternative.
What other medicines interact with Fondaparinux?
MediHelp also lists interactions of Fondaparinux with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Fondaparinux page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
