Drug interactions
Fondaparinux + Protamine
Severity: Moderate
Fondaparinux and Protamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protamine is only partly effective at neutralising fondaparinux because it does not bind fondaparinux well. It should not be relied upon as a reversal agent.
What this interaction means in plain words
Fondaparinux and Protamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Protamine binds heparin by charge, but fondaparinux's short pentasaccharide is poorly neutralised.
What to do
Do not rely on protamine to reverse fondaparinux bleeding; use supportive care and local hemostasis. Consider other measures per local protocol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fondaparinux
- Defibrotide + Fondaparinux Contraindicated
- Fondaparinux + Ketorolac Contraindicated
- Abciximab + Fondaparinux Major
- Aceclofenac + Fondaparinux Major
- Acetylsalicylic acid + Fondaparinux Major
- Alteplase + Fondaparinux Major
Frequently asked questions
Can I take Fondaparinux with Protamine?
MediHelp rates the interaction as moderate. Fondaparinux and Protamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protamine is only partly effective at neutralising fondaparinux because it does not bind fondaparinux well. It should not be relied upon as a reversal agent.
How serious is the interaction between Fondaparinux and Protamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not rely on protamine to reverse fondaparinux bleeding; use supportive care and local hemostasis. Consider other measures per local protocol.
What other medicines interact with Fondaparinux?
MediHelp also lists interactions of Fondaparinux with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Fondaparinux page.
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