Drug interactions
Fondaparinux + Vorapaxar
Severity: Major
Fondaparinux and Vorapaxar: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorapaxar is a PAR-1 platelet antagonist that raises bleeding risk, and combining it with an anticoagulant adds to this risk. Vorapaxar is contraindicated in patients with prior stroke, TIA or intracranial hemorrhage.
What this interaction means in plain words
Fondaparinux and Vorapaxar can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive effects of platelet PAR-1 inhibition and factor Xa inhibition.
What to do
Avoid unless benefit clearly outweighs risk, and monitor closely for bleeding and hemoglobin changes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fondaparinux
- Defibrotide + Fondaparinux Contraindicated
- Fondaparinux + Ketorolac Contraindicated
- Abciximab + Fondaparinux Major
- Aceclofenac + Fondaparinux Major
- Acetylsalicylic acid + Fondaparinux Major
- Alteplase + Fondaparinux Major
Frequently asked questions
Can I take Fondaparinux with Vorapaxar?
MediHelp rates the interaction as major. Fondaparinux and Vorapaxar can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vorapaxar is a PAR-1 platelet antagonist that raises bleeding risk, and combining it with an anticoagulant adds to this risk. Vorapaxar is contraindicated in patients with prior stroke, TIA or intracranial hemorrhage.
How serious is the interaction between Fondaparinux and Vorapaxar?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless benefit clearly outweighs risk, and monitor closely for bleeding and hemoglobin changes.
What other medicines interact with Fondaparinux?
MediHelp also lists interactions of Fondaparinux with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Fondaparinux page.
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