Drug interactions
Formoterol + Hydrochlorothiazide-lisinopril
Severity: Moderate
Formoterol and Hydrochlorothiazide-lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Formoterol can lower serum potassium, and this may add to thiazide-induced hypokalemia. Significant hypokalemia increases the risk of arrhythmias, particularly with high doses or in acute asthma or COPD exacerbations.
What this interaction means in plain words
Formoterol and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Formoterol belongs to Respiratory; Hydrochlorothiazide-lisinopril belongs to Cardiovascular.
Why it happens
Beta-2 agonist driven cellular potassium uptake adds to renal potassium loss caused by the thiazide.
What to do
Monitor serum potassium in patients on high-dose formoterol or with acute illness and replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Other interactions of Formoterol
- Adagrasib + Formoterol Major
- Amiodarone + Formoterol Major
- Amisulpride + Formoterol Major
- Amitriptyline + Formoterol Major
- Amoxapine + Formoterol Major
- Arformoterol + Formoterol Major
Frequently asked questions
Can I take Formoterol with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as moderate. Formoterol and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Formoterol can lower serum potassium, and this may add to thiazide-induced hypokalemia. Significant hypokalemia increases the risk of arrhythmias, particularly with high doses or in acute asthma or COPD exacerbations.
How serious is the interaction between Formoterol and Hydrochlorothiazide-lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients on high-dose formoterol or with acute illness and replace potassium as needed.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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