Drug interactions
Formoterol-mometasone + Givinostat
Severity: Moderate
Formoterol-mometasone and Givinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givinostat can prolong the QTc interval, and formoterol may add to this effect. The combination raises the risk of ventricular arrhythmias including torsades de pointes.
What this interaction means in plain words
Formoterol-mometasone and Givinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Formoterol-mometasone belongs to Respiratory; Givinostat belongs to Miscellaneous.
Why it happens
Additive effects on cardiac repolarization.
What to do
Obtain ECGs at initiation and during concomitant use, and withhold givinostat if QTc exceeds 500 ms or rises more than 60 ms from baseline. Keep potassium and magnesium within normal range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Formoterol-mometasone
Other interactions of Givinostat
- Abiraterone + Givinostat Major
- Amiodarone + Givinostat Major
- Amisulpride + Givinostat Major
- Amitriptyline + Givinostat Major
- Anagrelide + Givinostat Major
- Asenapine + Givinostat Major
Frequently asked questions
Can I take Formoterol-mometasone with Givinostat?
MediHelp rates the interaction as moderate. Formoterol-mometasone and Givinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givinostat can prolong the QTc interval, and formoterol may add to this effect. The combination raises the risk of ventricular arrhythmias including torsades de pointes.
How serious is the interaction between Formoterol-mometasone and Givinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain ECGs at initiation and during concomitant use, and withhold givinostat if QTc exceeds 500 ms or rises more than 60 ms from baseline. Keep potassium and magnesium within normal range.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Amoxapine. The full list is on the Formoterol-mometasone page.
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