Drug interactions
Formoterol-mometasone + Ketoconazole
Severity: Moderate
Formoterol-mometasone and Ketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole prolongs QT and inhibits CYP3A4, which may modestly increase systemic formoterol exposure. Together with formoterol hypokalemia, this raises arrhythmia risk.
What this interaction means in plain words
Formoterol-mometasone and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Formoterol-mometasone belongs to Respiratory; Ketoconazole belongs to Anti Fungals.
Why it happens
Additive QT prolongation, with CYP3A4 inhibition by ketoconazole also raising mometasone exposure.
What to do
Monitor ECG and potassium; watch for corticosteroid systemic effects with prolonged use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Formoterol-mometasone
Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Formoterol-mometasone with Ketoconazole?
MediHelp rates the interaction as moderate. Formoterol-mometasone and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole prolongs QT and inhibits CYP3A4, which may modestly increase systemic formoterol exposure. Together with formoterol hypokalemia, this raises arrhythmia risk.
How serious is the interaction between Formoterol-mometasone and Ketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and potassium; watch for corticosteroid systemic effects with prolonged use.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Amoxapine. The full list is on the Formoterol-mometasone page.
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