Drug interactions
Formoterol-mometasone + Lofexidine
Severity: Moderate
Formoterol-mometasone and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine can prolong the QT interval and cause bradycardia and hypotension, and formoterol may add QT effects and hypokalemia. Together they may increase arrhythmia risk.
What this interaction means in plain words
Formoterol-mometasone and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Formoterol-mometasone belongs to Respiratory; Lofexidine belongs to Central Nervous System.
Why it happens
Additive QT prolongation with beta-2 agonist related hypokalemia.
What to do
Obtain ECG and correct electrolytes in patients with QT risk factors, and monitor heart rate and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Formoterol-mometasone
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Formoterol-mometasone with Lofexidine?
MediHelp rates the interaction as moderate. Formoterol-mometasone and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofexidine can prolong the QT interval and cause bradycardia and hypotension, and formoterol may add QT effects and hypokalemia. Together they may increase arrhythmia risk.
How serious is the interaction between Formoterol-mometasone and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain ECG and correct electrolytes in patients with QT risk factors, and monitor heart rate and blood pressure.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Amoxapine. The full list is on the Formoterol-mometasone page.
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