Drug interactions
Formoterol-mometasone + Methadone
Severity: Moderate
Formoterol-mometasone and Methadone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both formoterol and methadone can prolong the QTc interval, so using them together may add to the risk of torsades de pointes, particularly in patients with other risk factors such as hypokalemia or structural heart disease. Beta-agonists can also lower serum potassium, which further increases arrhythmic susceptibility.
What this interaction means in plain words
Formoterol-mometasone and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Formoterol-mometasone belongs to Respiratory; Methadone belongs to Musculoskeletal.
Why it happens
Additive QT prolongation through pharmacodynamic effects, with beta-agonist-induced hypokalemia as a contributing factor.
What to do
Obtain a baseline ECG and monitor QTc after starting or adjusting either drug, and correct potassium and magnesium abnormalities. Consider alternatives or dose reduction if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Formoterol-mometasone
Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Frequently asked questions
Can I take Formoterol-mometasone with Methadone?
MediHelp rates the interaction as moderate. Formoterol-mometasone and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both formoterol and methadone can prolong the QTc interval, so using them together may add to the risk of torsades de pointes, particularly in patients with other risk factors such as hypokalemia or structural heart disease. Beta-agonists can also lower serum potassium, which further increases arrhythmic susceptibility.
How serious is the interaction between Formoterol-mometasone and Methadone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc after starting or adjusting either drug, and correct potassium and magnesium abnormalities. Consider alternatives or dose reduction if QTc becomes markedly prolonged.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Amoxapine. The full list is on the Formoterol-mometasone page.
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