Drug interactions
Formoterol-mometasone + Nelfinavir
Severity: Moderate
Formoterol-mometasone and Nelfinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir inhibits CYP3A4 and can raise systemic mometasone exposure. Prolonged coadministration may lead to Cushing syndrome and adrenal suppression.
What this interaction means in plain words
Formoterol-mometasone and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Formoterol-mometasone belongs to Respiratory; Nelfinavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4-mediated mometasone metabolism by nelfinavir.
What to do
Consider switching to beclomethasone or another corticosteroid less affected by CYP3A4 for long-term therapy; otherwise monitor for corticosteroid adverse effects and adrenal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Formoterol-mometasone and Nelfinavir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Formoterol-mometasone
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Formoterol-mometasone with Nelfinavir?
MediHelp rates the interaction as moderate. Formoterol-mometasone and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nelfinavir inhibits CYP3A4 and can raise systemic mometasone exposure. Prolonged coadministration may lead to Cushing syndrome and adrenal suppression.
How serious is the interaction between Formoterol-mometasone and Nelfinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider switching to beclomethasone or another corticosteroid less affected by CYP3A4 for long-term therapy; otherwise monitor for corticosteroid adverse effects and adrenal function.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Amoxapine. The full list is on the Formoterol-mometasone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
