Drug interactions
Formoterol-mometasone + Pasireotide
Severity: Moderate
Formoterol-mometasone and Pasireotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pasireotide prolongs the QT interval and causes bradycardia, and formoterol may add a small QT effect, mainly at higher doses. The combined risk of arrhythmia is greatest with hypokalaemia or existing heart disease.
What this interaction means in plain words
Formoterol-mometasone and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Formoterol-mometasone belongs to Respiratory; Pasireotide belongs to Endocrine.
Why it happens
Additive QT-prolonging pharmacodynamic effects, with formoterol-induced hypokalaemia potentially increasing susceptibility.
What to do
Check ECG and serum potassium and magnesium before and during treatment, and correct any deficits. Avoid exceeding the recommended formoterol dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Formoterol-mometasone
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
Frequently asked questions
Can I take Formoterol-mometasone with Pasireotide?
MediHelp rates the interaction as moderate. Formoterol-mometasone and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pasireotide prolongs the QT interval and causes bradycardia, and formoterol may add a small QT effect, mainly at higher doses. The combined risk of arrhythmia is greatest with hypokalaemia or existing heart disease.
How serious is the interaction between Formoterol-mometasone and Pasireotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and serum potassium and magnesium before and during treatment, and correct any deficits. Avoid exceeding the recommended formoterol dose.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Amoxapine. The full list is on the Formoterol-mometasone page.
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