Drug interactions
Formoterol-mometasone + Pazopanib
Severity: Moderate
Formoterol-mometasone and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib is labeled for QT prolongation and torsades de pointes, and formoterol can also affect repolarization and lower potassium. Using them together may increase the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Formoterol-mometasone and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Formoterol-mometasone belongs to Respiratory; Pazopanib belongs to Oncology.
Why it happens
Additive QTc prolongation, with beta-2-agonist-induced hypokalemia potentially amplifying the effect.
What to do
Obtain a baseline ECG and electrolytes and repeat periodically during co-therapy. Correct hypokalemia and hypomagnesemia, and reassess the need for formoterol if the QTc lengthens markedly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Formoterol-mometasone
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Formoterol-mometasone with Pazopanib?
MediHelp rates the interaction as moderate. Formoterol-mometasone and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib is labeled for QT prolongation and torsades de pointes, and formoterol can also affect repolarization and lower potassium. Using them together may increase the risk of serious ventricular arrhythmia.
How serious is the interaction between Formoterol-mometasone and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and electrolytes and repeat periodically during co-therapy. Correct hypokalemia and hypomagnesemia, and reassess the need for formoterol if the QTc lengthens markedly.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Amoxapine. The full list is on the Formoterol-mometasone page.
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