Drug interactions
Formoterol-mometasone + Propranolol
Severity: Major
Formoterol-mometasone and Propranolol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol is a non-selective beta-blocker that blocks the bronchodilating action of formoterol and can provoke bronchospasm in patients with asthma or COPD. The combination can therefore reduce asthma control and cause severe attacks.
What this interaction means in plain words
Formoterol-mometasone and Propranolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Formoterol-mometasone belongs to Respiratory; Propranolol belongs to Cardiovascular.
Why it happens
Competitive antagonism of beta-2 receptors by propranolol opposes formoterol's bronchodilation.
What to do
Avoid non-selective beta-blockers in patients with asthma and generally in those needing formoterol. If a beta-blocker is essential, choose a cardioselective agent at the lowest dose with respiratory monitoring.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Formoterol-mometasone
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Formoterol-mometasone with Propranolol?
MediHelp rates the interaction as major. Formoterol-mometasone and Propranolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Propranolol is a non-selective beta-blocker that blocks the bronchodilating action of formoterol and can provoke bronchospasm in patients with asthma or COPD. The combination can therefore reduce asthma control and cause severe attacks.
How serious is the interaction between Formoterol-mometasone and Propranolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid non-selective beta-blockers in patients with asthma and generally in those needing formoterol. If a beta-blocker is essential, choose a cardioselective agent at the lowest dose with respiratory monitoring.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Amoxapine. The full list is on the Formoterol-mometasone page.
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