Drug interactions
Forskolin + Mefenamic acid
Severity: Moderate
Forskolin and Mefenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Forskolin raises cyclic AMP and may inhibit platelet aggregation, so it could add to the bleeding risk of NSAIDs. Clinical data are scant and the interaction is mainly theoretical.
What this interaction means in plain words
Forskolin and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet effect via adenylate cyclase activation by forskolin and COX inhibition by mefenamic acid.
What to do
Monitor for bruising and bleeding, and avoid combining in patients with bleeding disorders or ulcer history.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Forskolin with Mefenamic acid?
MediHelp rates the interaction as moderate. Forskolin and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Forskolin raises cyclic AMP and may inhibit platelet aggregation, so it could add to the bleeding risk of NSAIDs. Clinical data are scant and the interaction is mainly theoretical.
How serious is the interaction between Forskolin and Mefenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bruising and bleeding, and avoid combining in patients with bleeding disorders or ulcer history.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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