Drug interactions
Fosamprenavir + Insulin glargine
Severity: Moderate
Fosamprenavir and Insulin glargine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
HIV protease inhibitors can cause insulin resistance and hyperglycemia, which may reduce the effectiveness of a given insulin dose. Patients with diabetes may need more insulin after starting therapy.
What this interaction means in plain words
Fosamprenavir and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Protease inhibitors reduce peripheral glucose uptake, in part by impairing GLUT4 function, and may impair insulin secretion, leading to insulin resistance.
What to do
Check blood glucose more often after starting or changing the protease inhibitor and titrate insulin glargine upward as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fosamprenavir and Insulin glargine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Insulin glargine
Frequently asked questions
Can I take Fosamprenavir with Insulin glargine?
MediHelp rates the interaction as moderate. Fosamprenavir and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. HIV protease inhibitors can cause insulin resistance and hyperglycemia, which may reduce the effectiveness of a given insulin dose. Patients with diabetes may need more insulin after starting therapy.
How serious is the interaction between Fosamprenavir and Insulin glargine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose more often after starting or changing the protease inhibitor and titrate insulin glargine upward as required.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
