Drug interactions
Fosamprenavir + Ivabradine
Severity: Contraindicated
Fosamprenavir and Ivabradine: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir is converted to amprenavir, a CYP3A4 inhibitor, and especially with ritonavir boosting can substantially increase ivabradine levels. This may cause serious bradycardia and conduction abnormalities.
What this interaction means in plain words
Fosamprenavir and Ivabradine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Amprenavir inhibits CYP3A4, reducing ivabradine metabolism.
What to do
Avoid the combination and select an alternative agent for angina or heart failure.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Ivabradine
- Atazanavir + Ivabradine Contraindicated
- Clarithromycin + Ivabradine Contraindicated
- Cobicistat + Ivabradine Contraindicated
- Conivaptan + Ivabradine Contraindicated
- Darunavir + Ivabradine Contraindicated
- Diltiazem + Ivabradine Contraindicated
Frequently asked questions
Can I take Fosamprenavir with Ivabradine?
MediHelp rates the interaction as contraindicated. Fosamprenavir and Ivabradine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fosamprenavir is converted to amprenavir, a CYP3A4 inhibitor, and especially with ritonavir boosting can substantially increase ivabradine levels. This may cause serious bradycardia and conduction abnormalities.
How serious is the interaction between Fosamprenavir and Ivabradine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and select an alternative agent for angina or heart failure.
What other medicines interact with Ivabradine?
MediHelp also lists interactions of Ivabradine with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Ivabradine page.
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