Drug interactions
Fosamprenavir + Lovastatin
Severity: Contraindicated
Fosamprenavir and Lovastatin: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir is converted to amprenavir, a CYP3A4 inhibitor, and the effect is increased when boosted with ritonavir. Lovastatin exposure rises, increasing the risk of myopathy and rhabdomyolysis, and concurrent use is contraindicated.
What this interaction means in plain words
Fosamprenavir and Lovastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Amprenavir, with or without ritonavir, inhibits CYP3A4, blocking lovastatin metabolism.
What to do
Do not combine. Use pravastatin or rosuvastatin, starting low, as an alternative.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Frequently asked questions
Can I take Fosamprenavir with Lovastatin?
MediHelp rates the interaction as contraindicated. Fosamprenavir and Lovastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fosamprenavir is converted to amprenavir, a CYP3A4 inhibitor, and the effect is increased when boosted with ritonavir. Lovastatin exposure rises, increasing the risk of myopathy and rhabdomyolysis, and concurrent use is contraindicated.
How serious is the interaction between Fosamprenavir and Lovastatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Use pravastatin or rosuvastatin, starting low, as an alternative.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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