Drug interactions
Fosamprenavir + Lurasidone
Severity: Contraindicated
Fosamprenavir and Lurasidone: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir (as amprenavir, often boosted with ritonavir) inhibits CYP3A4 and can raise lurasidone concentrations substantially. The higher exposure increases the risk of dose-related adverse effects such as extrapyramidal symptoms and sedation. Labeling contraindicates strong CYP3A4 inhibitors with lurasidone.
What this interaction means in plain words
Fosamprenavir and Lurasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Inhibition of CYP3A4-mediated metabolism of lurasidone.
What to do
Do not combine; select an alternative antipsychotic or antiretroviral regimen.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Fosamprenavir with Lurasidone?
MediHelp rates the interaction as contraindicated. Fosamprenavir and Lurasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fosamprenavir (as amprenavir, often boosted with ritonavir) inhibits CYP3A4 and can raise lurasidone concentrations substantially. The higher exposure increases the risk of dose-related adverse effects such as extrapyramidal symptoms and sedation. Labeling contraindicates strong CYP3A4 inhibitors with lurasidone.
How serious is the interaction between Fosamprenavir and Lurasidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; select an alternative antipsychotic or antiretroviral regimen.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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