Drug interactions
Fosamprenavir + Omeprazole
Severity: Minor
Fosamprenavir and Omeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir's active form amprenavir is not clearly dependent on gastric acid, and PPIs have been shown not to meaningfully reduce amprenavir exposure when fosamprenavir is used. Clinical effect is unlikely.
What this interaction means in plain words
Fosamprenavir and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Increased gastric pH is theorised to affect absorption but no significant effect has been demonstrated.
What to do
No dose adjustment is needed. Monitor virologic response as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Frequently asked questions
Can I take Fosamprenavir with Omeprazole?
MediHelp rates the interaction as minor. Fosamprenavir and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosamprenavir's active form amprenavir is not clearly dependent on gastric acid, and PPIs have been shown not to meaningfully reduce amprenavir exposure when fosamprenavir is used. Clinical effect is unlikely.
How serious is the interaction between Fosamprenavir and Omeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor virologic response as usual.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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