Drug interactions
Fosamprenavir + Rimegepant
Severity: Moderate
Fosamprenavir and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir (as amprenavir) is a moderate CYP3A4 inhibitor and can raise rimegepant exposure. This may increase the risk of rimegepant adverse effects.
What this interaction means in plain words
Fosamprenavir and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 metabolism of rimegepant by amprenavir.
What to do
When rimegepant is used for acute treatment, avoid a repeat dose within 48 hours. No change is needed for preventive use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fosamprenavir and Rimegepant, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Rimegepant
Frequently asked questions
Can I take Fosamprenavir with Rimegepant?
MediHelp rates the interaction as moderate. Fosamprenavir and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosamprenavir (as amprenavir) is a moderate CYP3A4 inhibitor and can raise rimegepant exposure. This may increase the risk of rimegepant adverse effects.
How serious is the interaction between Fosamprenavir and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: When rimegepant is used for acute treatment, avoid a repeat dose within 48 hours. No change is needed for preventive use.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
