Drug interactions
Fosaprepitant + Griseofulvin
Severity: Minor
Fosaprepitant and Griseofulvin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant is converted to aprepitant, which is cleared mainly by CYP3A4. Enzyme induction by griseofulvin may reduce aprepitant exposure and weaken antiemetic protection.
What this interaction means in plain words
Fosaprepitant and Griseofulvin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosaprepitant belongs to Gastrointestinal Tract; Griseofulvin belongs to Anti Fungals.
Why it happens
Griseofulvin induces CYP3A4, accelerating aprepitant metabolism.
What to do
Fosaprepitant is usually given as a single dose, so no adjustment is needed. Watch for breakthrough nausea and add rescue antiemetics if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Griseofulvin
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Griseofulvin?
MediHelp rates the interaction as minor. Fosaprepitant and Griseofulvin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant is converted to aprepitant, which is cleared mainly by CYP3A4. Enzyme induction by griseofulvin may reduce aprepitant exposure and weaken antiemetic protection.
How serious is the interaction between Fosaprepitant and Griseofulvin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Fosaprepitant is usually given as a single dose, so no adjustment is needed. Watch for breakthrough nausea and add rescue antiemetics if needed.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporin, Desogestrel-ethinyl estradiol, Dienogest / estradiol valerate. The full list is on the Griseofulvin page.
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