Drug interactions
Fosaprepitant + Sildenafil
Severity: Minor
Fosaprepitant and Sildenafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant, converted to aprepitant, is a weak-to-moderate CYP3A4 inhibitor, but a single dose produces only a short-lived effect on sildenafil. A clinically significant rise in sildenafil exposure is unlikely with single-dose use.
What this interaction means in plain words
Fosaprepitant and Sildenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosaprepitant belongs to Gastrointestinal Tract; Sildenafil belongs to Genitourinary.
Why it happens
Transient CYP3A4 inhibition by aprepitant slightly reduces sildenafil metabolism.
What to do
No dose adjustment is usually required. Counsel on possible dizziness and hypotension in the days after chemotherapy-related dosing.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Sildenafil?
MediHelp rates the interaction as minor. Fosaprepitant and Sildenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant, converted to aprepitant, is a weak-to-moderate CYP3A4 inhibitor, but a single dose produces only a short-lived effect on sildenafil. A clinically significant rise in sildenafil exposure is unlikely with single-dose use.
How serious is the interaction between Fosaprepitant and Sildenafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required. Counsel on possible dizziness and hypotension in the days after chemotherapy-related dosing.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
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