Drug interactions
Fosaprepitant + Zaleplon
Severity: Minor
Fosaprepitant and Zaleplon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant is converted to aprepitant, a moderate CYP3A4 inhibitor, which could slightly increase zaleplon exposure after a single dose. Zaleplon relies mostly on aldehyde oxidase, so the effect is probably small and short-lived.
What this interaction means in plain words
Fosaprepitant and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fosaprepitant belongs to Gastrointestinal Tract; Zaleplon belongs to Central Nervous System.
Why it happens
Aprepitant transiently inhibits CYP3A4, reducing the minor CYP3A4-mediated clearance of zaleplon.
What to do
No routine adjustment is needed; advise patients to watch for extra sedation after zaleplon on days fosaprepitant is given.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fosaprepitant and Zaleplon, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Zaleplon
- Calcium / magnesium / potassium / sodium oxybates + Zaleplon Contraindicated
- Sodium oxybate + Zaleplon Contraindicated
- Brexanolone + Zaleplon Major
- Buprenorphine long-acting + Zaleplon Major
- Buprenorphine subdermal implant + Zaleplon Major
- Buprenorphine transdermal + Zaleplon Major
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Fosaprepitant with Zaleplon?
MediHelp rates the interaction as minor. Fosaprepitant and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant is converted to aprepitant, a moderate CYP3A4 inhibitor, which could slightly increase zaleplon exposure after a single dose. Zaleplon relies mostly on aldehyde oxidase, so the effect is probably small and short-lived.
How serious is the interaction between Fosaprepitant and Zaleplon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; advise patients to watch for extra sedation after zaleplon on days fosaprepitant is given.
What other medicines interact with Zaleplon?
MediHelp also lists interactions of Zaleplon with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Brexanolone. The full list is on the Zaleplon page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
